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Showing posts from April, 2021

Early warning signals could help monitor disease outbreaks

New research suggests early warning signals (EWSs) could help in the monitoring of disease outbreaks, such as COVID-19. The study found warnings could be detected weeks earlier than any rapid increase in cases. The findings could help governments and policy makers improve the accuracy of their decisions and allow timely interventions if needed. from Top Health News -- ScienceDaily https://ift.tt/3DvxDk4 via IFTTT

Engineering T cells to attack cancer broadly

This study builds on decades of work showing that the protein IL-24 attacks cancer broadly, and is the first to deliver the protein using T cells. This approach is in contrast to CAR-T cells, which are built to recognize proteins on the surface of cancer cells and haven't been successful against solid tumors. Mice with prostate cancer experienced shrinkage of the original tumor as well as distant metastases following treatment with IL-24 T cells. from Top Health News -- ScienceDaily https://ift.tt/3aTWUsz via IFTTT

Move over CRISPR, the Retrons are coming

Researchers have created a new gene editing tool called Retron Library Recombineering (RLR) that can generate up to millions of mutations simultaneously, and 'barcodes' mutant bacterial cells so that the entire pool can be screened at once. It can be used in contexts where CRISPR is toxic or not feasible, and results in better editing rates. from Top Health News -- ScienceDaily https://ift.tt/3e4pwl1 via IFTTT

Light as a fairy tale: What makes a feel-good film feel good?

'Feel-good films' are usually dismissed by film critics as being sentimental and without intellectual merit. But their popularity with audiences, who seek them out precisely because of their 'feel-good' qualities, tells a more favorable story. Now, for the first time, this popular movie genre has been examined scientifically. from Top Health News -- ScienceDaily https://ift.tt/3xzo5Tk via IFTTT

Hippocampal maps predict context-dependent behavior

Successful navigation requires the ability to separate memories in a context-dependent manner. For example, to find lost keys, one must first remember whether the keys were left in the kitchen or the office. How does the human brain retrieve the contextual memories that drive behavior? from Top Health News -- ScienceDaily https://ift.tt/3e575fS via IFTTT

Shortage of DNA building blocks in the cell releases mitochondrial DNA

Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative diseases as well as the ageing process are linked to the mitochondrial genome. Researchers have investigated the reasons for the release of mitochondrial genetic material and found a direct link to cellular metabolism: when the cell's DNA building blocks are in short supply, mitochondria release their genetic material and trigger inflammation. The researchers hope to find new therapeutic approaches by influencing this metabolic pathway. from Top Health News -- ScienceDaily https://ift.tt/3ua8zLs via IFTTT

How diet controls RNA maturation

Particularly sensitive to chemical modifications, mRNAs are molecules responsible for transmitting the information encoded in our genome, allowing for the synthesis of proteins. Two teams have focused on a specific type of chemical modification - called methylation - of mRNA molecules in the small worm Caenorhabditis elegans. They found that methylation on a particular sequence of an mRNA leads to its degradation and that this control mechanism depends on the worm's diet. from Top Health News -- ScienceDaily https://ift.tt/3nEOSJw via IFTTT

How meningitis-causing bacteria may sense fever to avoid immune killing

Researchers have discovered a mechanism through which meningitis-causing bacteria can evade our immune system. In laboratory tests, they found that Streptococcus pneumoniae and Haemophilus influenzae respond to increasing temperatures by producing safeguards that keep them from getting killed. This may prime their defenses against our immune system and increase their chances of survival, the researchers say. from Top Health News -- ScienceDaily https://ift.tt/2QAwZPX via IFTTT

Multi-drug resistant infection about to evolve within cystic fibrosis patients

Scientists have been able to track how a multi-drug resistant organism is able to evolve and spread widely among cystic fibrosis patients - showing that it can evolve rapidly within an individual during chronic infection. The researchers say their findings highlight the need to treat patients with Mycobacterium abscessus infection immediately, counter to current medical practice. from Top Health News -- ScienceDaily https://ift.tt/3e2EGaq via IFTTT

Structural changes in snap-frozen proteins

Researchers have succeeded in ultra-fast freezing proteins after a precisely defined period of time. They were able to follow structural changes on the microsecond time scale and with sub-nanometer precision. Owing to its high spatial and temporal resolution, the method allows tracking rapid structural changes in enzymes and nucleic acids. from Top Health News -- ScienceDaily https://ift.tt/3gShbCz via IFTTT

Childhood psychiatric symptom risk strongly linked to adverse exposures during gestation

Adverse environmental exposures during pregnancy -- including those that occur before pregnancy is recognized -- have a sizable effect on risk for psychiatric symptoms in childhood. Researchers are working to discover, develop and implement early life interventions that can mitigate some of these risks. from Top Health News -- ScienceDaily https://ift.tt/3ujOYsB via IFTTT

Driving behaviors harbor early signals of dementia

Using naturalistic driving data and machine learning techniques, researchers have developed highly accurate algorithms for detecting mild cognitive impairment and dementia in older drivers. Naturalistic driving data refer to data captured through in-vehicle recording devices or other technologies in the real-world setting. These data could be processed to measure driving exposure, space and performance in great detail. from Top Health News -- ScienceDaily https://ift.tt/2QARewX via IFTTT

New atlas of genetic function maps complexities of immune system and immune diseases

A new genetic database for autoimmune and autoinflammatory diseases will allow experts to more deeply understand how immune disorders develop and plan future drug discovery projects. Scientists also hope this atlas of immune-related genome data may eventually be applied to investigations of infectious diseases like COVID-19. from Top Health News -- ScienceDaily https://ift.tt/3u5VcvW via IFTTT

Single-cell CRISPR technology deciphers role of chromatin accessibility in cancer

Researchers have developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new method harnesses the programmability of the gene editing system CRISPR to knock-out nearly all chromatin-related genes in parallel, offering researchers deeper insights into the role of DNA accessibility in cancer and in rare diseases involving chromatin. from Top Health News -- ScienceDaily https://ift.tt/3aKqil9 via IFTTT

Baby's first stool can help predict risk of developing allergies

Researchers have shown that the composition of a baby's first feces -- a thick, dark green substance known as meconium -- is associated with whether or not a child will develop allergies within their first year of life. By analyzing meconium samples from 100 infants, they show that the development of a healthy immune system and microbiota may start well before a child is born. from Top Health News -- ScienceDaily https://ift.tt/3u38ppm via IFTTT

A psychologist's guide to donating more effectively to charities

Donating to a charity is often driven by emotion rather than by calculated assessments based on how to make the biggest impact. A new article looks at how people can be encouraged to direct their charitable contributions in ways that allow them to get more bang for the buck. from Top Health News -- ScienceDaily https://ift.tt/3gO8YQ7 via IFTTT

How does the brain flexibly process complex information?

Human decision-making depends on the flexible processing of complex information, but how the brain may adapt processing to momentary task demands has remained unclear. Researchers have now outlined several crucial neural processes revealing that our brain networks may rapidly and flexibly shift from a rhythmic to a 'noisy' state when the need to process information increases. from Top Health News -- ScienceDaily https://ift.tt/3gKNp2R via IFTTT

Diseases affect brain's networks selectively, BrainMap analysis affirms

Researchers studied 43 brain disorders and strongly affirmed a theory called the 'network degeneration hypothesis.' This theory holds that disease-related structural damage invades functional networks used in human behavior and often repeats in 'co-alteration networks.' from Top Health News -- ScienceDaily https://ift.tt/2QGfLAC via IFTTT

A new strain of a well-known probiotic might offer help for infants' intestinal problems

A new strain of the Lacticaseibacillus rhamnosus GG probiotic is able to utilise both lactose and casein as well as reproduce in dairy products. The discovery can make it unnecessary to separately add the probiotic to dairy products, in addition to which it could fare better in the intestine, boosting gut health. from Top Health News -- ScienceDaily https://ift.tt/3u68sR0 via IFTTT

Expressing variety of emotions earns entrepreneurs funding

Despite perceptions that entrepreneurs should always be positive about their ventures, a study found that entrepreneurs whose facial expressions moved through a mix of happiness, anger and fear during funding pitches were more successful. Researchers analyzed nearly 500 pitch videos from the online crowdfunding site Kickstarter. Those who varied their emotional expressions had more success on meeting their goal, total amount raised and number of contributors. from Top Health News -- ScienceDaily https://ift.tt/32WbFH0 via IFTTT

Team builds better tool for assessing infant brain health

Researchers have created a new, open-access tool that allows doctors and scientists to evaluate infant brain health by assessing the concentration of various chemical markers, called metabolites, in the brain. The tool compiled data from 140 infants to determine normal ranges for these metabolites. from Top Health News -- ScienceDaily https://ift.tt/3vs9aIL via IFTTT

Preclinical discovery triggers wound healing, skin regeneration

Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The research team documented restoration of skin integrity, hair follicles, sweat glands, skin oils and normal hydration. from Top Health News -- ScienceDaily https://ift.tt/3u5iySu via IFTTT

Processed diets might promote chronic infections that can lead to disorders such as diabetes

Processed diets, which are low in fiber, may initially reduce the incidence of foodborne infectious diseases such as E. coli infections, but might also increase the incidence of diseases characterized by low-grade chronic infection and inflammation such as diabetes, according to researchers. from Top Health News -- ScienceDaily https://ift.tt/2Sfkc61 via IFTTT

Stress slows the immune response in sick mice

The neurotransmitter noradrenaline, which plays a key role in the fight-or-flight stress response, impairs immune responses by inhibiting the movements of various white blood cells in different tissues, researchers report. The fast and transient effect occurred in mice with infections and cancer, but for now, it's unclear whether the findings generalize to humans with various health conditions. from Top Health News -- ScienceDaily https://ift.tt/3ey17Dq via IFTTT

Researchers identify a psychedelic-like drug without the hallucinogenic side effects

Psychedelic drugs have shown promise for treating neuropsychiatric disorders like depression and posttraumatic stress disorder. However, due to their hallucinatory side effects, some researchers are trying to identify drugs that could offer the benefits of psychedelics without causing hallucinations. Researchers now report they have identified one such drug through the development of a genetically encoded fluorescent sensor -- called psychLight -- that can screen for hallucinogenic potential. from Top Health News -- ScienceDaily https://ift.tt/3aNXAQd via IFTTT

Childhood air pollution exposure linked to poor mental health at age 18

Childhood exposure to air pollution, such as nitrogen oxides and fine particulate matter, is a risk factor for mental illness at age 18. It is less of a factor than family history, but equal to lead, according to a new study. The finding comes from a cohort of 2,000 twins born in England and Wales in 1994-1995 and followed to young adulthood. from Top Health News -- ScienceDaily https://ift.tt/3t4AlHY via IFTTT

Brazilian coronavirus variant likely to be more transmissible and able to evade immunity, study finds

A new study indicates that the coronavirus variant called P.1, which originated in Brazil, could pose a bigger threat than previously assumed. The researchers conclude that it is likely that P.1 is more transmissible than other strains of SARS-Cov2 and that might be able to evade immunity gained from previous infection with coronavirus. from Top Health News -- ScienceDaily https://ift.tt/3nryufe via IFTTT

Treating severe COVID-19 cases

Long non-coding RNA molecules (lncRNAs) are potential regulators of anti-viral response during severe SARS-CoV-2 infection. Researchers constructed a gene co-expression network that measures the relationship of gene expression patterns across a group of samples. They identified four differentially expressed lncRNAs strongly correlated to the protein-coding genes in a novel network enriched for different immune-related processes associated with dysregulated cytokine production. The four were identified as 'hubs', signifying their association with cytokine over-production due to fierce immune response. from Top Health News -- ScienceDaily https://ift.tt/3xuky8N via IFTTT

Major advance enables study of genetic mutations in any tissue

For the first time, scientists are able to study changes in the DNA of any human tissue, following the resolution of long-standing technical challenges. The new method, called nanorate sequencing (NanoSeq), makes it possible to study how genetic changes occur in human tissues with unprecedented accuracy. from Top Health News -- ScienceDaily https://ift.tt/3nsA8NA via IFTTT

New model may explain the mystery of asymmetry in Parkinson's disease

Parkinson's disease (PD) is characterized by slowness of movement and tremors, which often appear asymmetrically in patients. The new model of PD may explain these perplexing asymmetrical motor symptoms and other known variations such as different degrees of constipation and sleep disorders. from Top Health News -- ScienceDaily https://ift.tt/2S6WE2V via IFTTT

Ageing impairs critical final egg maturation stage

Age may influence an a human egg cell's ability to process gene products essential for the last steps of its development. The final maturation stage is critical for reproduction because it provides the material early embryos need to develop normally and survive. The researchers also found that abnormal BMI also impacted oocyte development, but through different root mechanisms compared to the fertility decline caused by age. from Top Health News -- ScienceDaily https://ift.tt/2QHC4po via IFTTT

Household aerosols now release more harmful smog chemicals than all UK vehicles

Aerosol products used in the home now emit more harmful volatile organic compound (VOC) air pollution than all the vehicles in the UK, new research shows. A new study reveals that the picture is damaging globally with the world's population now using huge numbers of disposable aerosols - more than 25 billion cans per year. from Top Health News -- ScienceDaily https://ift.tt/2QHGg8F via IFTTT

Espresso, latte or decaf? Genetic code drives your desire for coffee

Whether you hanker for a hard hit of caffeine or favor the frothiness of a milky cappuccino, your regular coffee order could be telling you more about your cardio health than you think. In a new study of 390,435 people, researchers found causal genetic evidence that cardio health - as reflected in blood pressure and heart rate - influences coffee consumption. from Top Health News -- ScienceDaily https://ift.tt/3gJJ7bM via IFTTT

Scientists reveal how brain cells in Alzheimer's go awry, lose their identity

Despite the prevalence of Alzheimer's, there are still no treatments, in part because it has been challenging to study how the disease develops. Now, scientists have uncovered new insights into what goes awry during Alzheimer's by growing neurons that resemble -- more accurately than ever before -- brain cells in older patients. And like patients themselves, the afflicted neurons appear to lose their cellular identity. from Top Health News -- ScienceDaily https://ift.tt/3vtJQSP via IFTTT

Neural implant monitors multiple brain areas at once, provides new neuroscience insights

How do different parts of the brain communicate with each other during learning and memory formation? A new study takes a first step at answering this fundamental neuroscience question, thanks to a neural implant that monitors multiple brain regions at the same time. from Top Health News -- ScienceDaily https://ift.tt/32Q7VqC via IFTTT

Hepatitis C drugs combined with Remdesivir show strong effectiveness against COVID-19, study finds

A combination of remdesivir, a drug currently approved in the United States for treating COVID-19 patients, and repurposed drugs for hepatitis C virus (HCV) was 10 times more effective at inhibiting SARS-CoV-2, the virus that causes COVID-19, a study found. from Top Health News -- ScienceDaily https://ift.tt/3xvZDSX via IFTTT

Few young adult men have gotten the HPV vaccine

Using data from the 2010-2018 National Health Interview Surveys, researchers found that just 16% of men who were 18 to 21 years old had received at least one dose of the HPV vaccine at any age. In comparison, 42% of women in the same age bracket had gotten at least one shot of the vaccine. from Top Health News -- ScienceDaily https://ift.tt/2PsmoWF via IFTTT

Breastfeeding linked to higher neurocognitive testing scores in offspring

New research finds that children who were breastfed scored higher on neurocognitive tests. Researchers analyzed thousands of cognitive tests taken by nine and ten-year-olds whose mothers reported they were breastfed, and compared those results to scores of children who were not. from Top Health News -- ScienceDaily https://ift.tt/2QEfFt4 via IFTTT

Comprehensive single-cell atlas of human teeth

Researchers have mapped the first complete atlas of single cells that make up the human teeth. Their research shows that the composition of human dental pulp and periodontium vary greatly. Their findings open up new avenues for cell-based dental therapeutic approaches. from Top Health News -- ScienceDaily https://ift.tt/3vr89R1 via IFTTT

How oxygen radicals protect against cancer

Oxygen radicals in the body are generally considered dangerous because they can trigger something called oxidative stress, which is associated with the development of many chronic diseases such as cancer and cardiovascular disease. In studies on mice, scientists have now discovered how oxygen radicals, conversely, can also reduce the risk of cancer and mitigate damage to the hereditary molecule DNA. from Top Health News -- ScienceDaily https://ift.tt/3tRrRVT via IFTTT

Skin and bones repaired by bioprinting during surgery

Fixing traumatic injuries to the skin and bones of the face and skull is difficult because of the many layers of different types of tissues involved, but now, researchers have repaired such defects in a rat model using bioprinting during surgery, and their work may lead to faster and better methods of healing skin and bones. from Top Health News -- ScienceDaily https://ift.tt/32RoBhh via IFTTT

A new perspective on the genomes of archaic humans

Researchers examined 14,000 genetic differences between modern humans and our most recent ancestors at a new level of detail. They found that differences in gene activation - not just genetic code - could underlie evolution of the brain and vocal tract. from Top Health News -- ScienceDaily https://ift.tt/3ezpJvn via IFTTT

A new way of rapidly counting and identifying viruses

A professor has introduced a new concept for rapidly analyzing for the presence of a virus from colds to coronaviruses. However, although the concept can identify that someone has a type of coronavirus for example, it would not be able to determine the type of coronavirus, or variants. Additional tests would still be required to find out the specific virus someone was infected with. from Top Health News -- ScienceDaily https://ift.tt/3aEAlrM via IFTTT

Can a newborn's brain discriminate speech sounds?

People's ability to perceive speech sounds has been deeply studied, specially during someone's first year of life, but what happens during the first hours after birth? Are babies born with innate abilities to perceive speech sounds, or do neural encoding processes need to age for some time? from Top Health News -- ScienceDaily https://ift.tt/32ScmRL via IFTTT

Bacteria and viruses infect our cells through sugars: Now researchers want to know how they do it

Most infectious bacteria and viruses bind to sugars on the surface of our cells. Now researchers have created a library of tens of thousands of natural cells containing all the sugars found on the surface of our cells. The library may help us understand the role played by sugars and their receptors in the immune system and the brain, the researchers behind the study explain. from Top Health News -- ScienceDaily https://ift.tt/3aBbAgj via IFTTT

Newly discovered immune cell function vital to healing

Cardiovascular disease, the most common cause of death, is the result of oxygen deprivation as blood perfusion to affected tissue is prevented. To halt the development of the disease and to promote healing, re-establishment of blood flow is crucial. Researchers have now discovered that one of the most common immune cells in the human body, macrophages, play an important role in re-establishing and controlling blood flow, something that can be used to develop new drugs. from Top Health News -- ScienceDaily https://ift.tt/3eqEYXK via IFTTT

Muscle gene linked to type 2 diabetes

People with type 2 diabetes tend to have poorer muscle function than others. Now a research team has discovered that in type 2 diabetes, a specific gene is of great importance for the ability of muscle stem cells to create new mature muscle cells. from Top Health News -- ScienceDaily https://ift.tt/3ep4vQW via IFTTT

Skeletal defects may be ameliorated after immobility in the womb

Researchers have discovered that some skeletal defects associated with a lack of movement in the womb during early development may still be ameliorated after such periods of immobility if movement resumes. The discovery was made using chicken embryos, which develop similarly to their human equivalents and which can be easily viewed as development takes place - raising hopes that the finding may also apply to humans and thus have important implications for therapeutic interventions. from Top Health News -- ScienceDaily https://ift.tt/3tUnc5K via IFTTT

How philosophy can change the understanding of pain

Researchers have investigated how philosophical approaches can be used to think in new ways about pain and its management. The researchers advocate not merely reducing chronic pain management to searching and treating underlying physical changes but instead adopting an approach that focuses on the person as a whole. from Top Health News -- ScienceDaily https://ift.tt/3exwvC9 via IFTTT

Teaching pupils to 'think like Da Vinci' will help them to take on climate change

Reforms to the school curriculum which mix the arts and sciences, so that these subjects 'teach together' around common themes like climate change and food security, will better prepare young people for the real-world challenges that will define their adult lives, researchers argue in a new paper. from Top Health News -- ScienceDaily https://ift.tt/3aE33sZ via IFTTT

Researchers trace spinal neuron family tree

Spinal cord nerve cells branching through the body resemble trees with limbs fanning out in every direction. But this image can also be used to tell the story of how these neurons, their jobs becoming more specialized over time, arose through developmental and evolutionary history. Researchers have traced the development of spinal cord neurons using genetic signatures and revealed how different subtypes of the cells may have evolved and ultimately function to regulate body movements. from Top Health News -- ScienceDaily https://ift.tt/3vbxxub via IFTTT

Salad or cheeseburger? Your co-workers shape your food choices

Employees' cafeteria purchases -- both healthy and unhealthy foods -- were influenced by their co-workers' food choices, found a large, two-year study of hospital employees. The study made innovative use of cash register data to gain insights into how individuals' social networks shape their health behavior. The research suggests we might structure future efforts aimed at improving population health by capitalizing on how one person's behavior influences another. from Top Health News -- ScienceDaily https://ift.tt/3dHOA0V via IFTTT

MERS DNA vaccine induces immunity, protects from virus challenge in preclinical model

A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) induced potent immune responses and afforded protective efficacy in non-human primate models when given intradermally in abbreviated, low-dose immunization regimen. from Top Health News -- ScienceDaily https://ift.tt/3tOAi47 via IFTTT

Researchers show how 'theory of mind' influences advertising skepticism

Product marketers should be clear in their messaging to avoid customer skepticism that makes them feel duped, according to new research. At issue in a new study was a social-cognitive construct called theory of mind, which considers how well people assess the mental states and apparent goals of others. Turns out, it affects a person's evaluation and willingness to buy a product. from Top Health News -- ScienceDaily https://ift.tt/3gAh8eQ via IFTTT

Changing views on atherosclerosis

Atherosclerosis -- hardening of the arteries -- is now involved in the majority of deaths worldwide, and advances in our understanding of the biology of the disease are changing traditional views and opening up new avenues for treatment. from Top Health News -- ScienceDaily https://ift.tt/2PhFqPr via IFTTT

Ankle exoskeleton enables faster walking

In lab tests, researchers found that an optimized ankle exoskeleton system increased participants' walking speed by about 40 percent compared with their regular speed. The researchers hope someday to help restore walking speed in older adults. from Top Health News -- ScienceDaily https://ift.tt/3sLTAWs via IFTTT

Immune system, not COVID virus, may pose greatest risk to pregnant women

Scientists investigated whether the COVID-19 virus could be affecting placental tissue of infected expectant mothers. Their analysis found that while evidence of the virus in the placenta is rare, the placenta in infected mothers tended to exhibit a much higher level of immune system activity than those of non-infected pregnant women, they report. from Top Health News -- ScienceDaily https://ift.tt/3gxY3d3 via IFTTT

Study of 'breakthrough' cases suggests COVID testing may be here to stay

Two new cases helped scientists confirm what many have come to suspect: that people can get infected by SARS-CoV-2 variants even after successful vaccination. The findings suggest continued testing may be needed to prevent future outbreaks in a post-vaccine world. from Top Health News -- ScienceDaily https://ift.tt/3nbatJ2 via IFTTT

Among COVID-19 survivors, an increased risk of death, serious illness

Researchers showed that COVID-19 survivors -- including those not sick enough to be hospitalized -- have an increased risk of death in the six months following diagnosis with the virus. They also have catalogued the numerous diseases associated with COVID-19, providing a big-picture overview of the long-term complications of COVID-19 and revealing the massive burden this disease is likely to place on the world's population in the coming years. from Top Health News -- ScienceDaily https://ift.tt/3awCaqT via IFTTT

Artificial intelligence model predicts which key of the immune system opens the locks of coronavirus

A new artificial intelligence (AI) method is helping researchers link immune cells to their targets and, for example, uncouple which white blood cells recognize SARS-CoV-2. The tool has broad applications in understanding the function of the immune system in infections, autoimmune disorders, and cancer. from Top Health News -- ScienceDaily https://ift.tt/3gwbxpG via IFTTT

More belly weight increases danger of heart disease even if BMI does not indicate obesity

Research on how obesity impacts the diagnosis, management and outcomes of heart and blood vessel disease, heart failure and arrhythmias is summarized in a new statement. Waist circumference, an indicator of abdominal obesity, should be regularly measured as it is a potential warning sign of increased cardiovascular disease risk. Interventions that lead to weight loss improve risk factors yet may not always lead to improvement in coronary artery disease outcomes. from Top Health News -- ScienceDaily https://ift.tt/3axZG6L via IFTTT

Higher mushroom consumption is associated with a lower risk of cancer

Higher mushroom consumption is associated with a lower risk of cancer, according to a new study. The systematic review and meta-analysis examined 17 cancer studies published from 1966 to 2020. Analyzing data from more than 19,500 cancer patients, researchers explored the relationship between mushroom consumption and cancer risk. from Top Health News -- ScienceDaily https://ift.tt/2Pdq2U6 via IFTTT

Creativity and community: How modern humans overcame the Neanderthals

A new study is the first-ever to identify the genes for creativity in Homo sapiens that distinguish modern humans from chimpanzees and Neanderthals. The research identified 267 genes that are found only in modern humans and likely play an important role in the evolution of the behavioral characteristics that set apart Homo sapiens, including creativity, self-awareness, cooperativeness, and healthy longevity. from Top Health News -- ScienceDaily https://ift.tt/3tIfDio via IFTTT

Fighting harmful bacteria with nanoparticles

Multi-resistant pathogens are a serious and increasing problem in today's medicine. Where antibiotics are ineffective, these bacteria can cause life-threatening infections. Researchers are currently developing nanoparticles that can be used to detect and kill multi-resistant pathogens that hide inside our body cells. The team published the study in the current issue of the journal Nanoscale. from Top Health News -- ScienceDaily https://ift.tt/3xeteQy via IFTTT

Collaborative research could help fine-tune the production of antimalarials, chemo drugs

Much of common pharmaceutical development today is the product of laborious cycles of tweaking and optimization. In each drug, a carefully concocted formula of natural and synthetic enzymes and ingredients works together to catalyze a desired reaction. But in early development, much of the process is spent determining what quantities of each enzyme to use to ensure a reaction occurs at a specific speed. from Top Health News -- ScienceDaily https://ift.tt/3esFSTm via IFTTT

Study explains 'cocktail party effect' in hearing impairment

Plenty of people struggle to make sense of a multitude of converging voices in a crowded room. Commonly known as the 'cocktail party effect,' people with hearing loss find it's especially difficult to understand speech in a noisy environment. New research suggests that, for some listeners, this may have less to do with actually discerning sounds. Instead, it may be a processing problem in which two ears blend different sounds together - a condition known as binaural pitch fusion. from Top Health News -- ScienceDaily https://ift.tt/3tK3pFZ via IFTTT

Mice master complex thinking with a remarkable capacity for abstraction

Categorization is the brain's tool to organize nearly everything we encounter in our daily lives. Grouping information into categories simplifies our complex world and helps us to react quickly and effectively to new experiences. Scientists have now shown that also mice categorize surprisingly well. The researchers identified neurons encoding learned categories and thereby demonstrated how abstract information is represented at the neuronal level. from Top Health News -- ScienceDaily https://ift.tt/2QebtQT via IFTTT

Wildfire smoke linked to skin disease

Wildfire smoke can trigger a host of respiratory and cardiovascular symptoms, ranging from runny nose and cough to a potentially life-threatening heart attack or stroke. A new study suggests that the dangers posed by wildfire smoke may also extend to the largest organ in the human body, and our first line of defense against outside threat: the skin. from Top Health News -- ScienceDaily https://ift.tt/3sIp2VE via IFTTT

Improved management of farmed peatlands could cut 500 million tons CO2

Substantial cuts in global greenhouse gas emissions could be achieved by raising water levels in agricultural peatlands, according to a new study in the journal Nature. A team of researchers led by the UK Centre for Ecology & Hydrology estimates halving drainage depths in these areas could cut emissions by around 500 million tonnes of carbon dioxide (CO2) a year, which equates to 1 per cent of all global greenhouse gas emissions caused by human activities. from Top Health News -- ScienceDaily https://ift.tt/3sGwtww via IFTTT

Bypassing broken genes

A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases. The method involves inserting a new, fully functional copy of the gene that displaces the mutated gene. from Top Health News -- ScienceDaily https://ift.tt/3v2NsL8 via IFTTT

Illuminating invisible bloody fingerprints with a fluorescent polymer

Careful criminals usually clean a scene, wiping away visible blood and fingerprints. However, prints made with trace amounts of blood, invisible to the naked eye, could remain. Dyes can detect these hidden prints, but the dyes don't work well on certain surfaces. Now, researchers have developed a fluorescent polymer that binds to blood in a fingerprint -- without damaging any DNA also on the surface -- to create high-contrast images. from Top Health News -- ScienceDaily https://ift.tt/3gt90MV via IFTTT

SARS-CoV-2: Infection induces antibodies capable of killing infected cells regardless of disease severity

Researchers demonstrated that SARS-CoV-2 infection induces polyfunctional antibodies. Beyond neutralization, these antibodies can activate NK cells or the complement system, leading to the destruction of infected cells. Polyfunctional antibodies were found in all individuals (symptomatic and asymptomatic). These findings show that infection induces antibodies capable of killing infected cells regardless of the severity of the disease. from Top Health News -- ScienceDaily https://ift.tt/3v6mAKg via IFTTT

New insights on inflammation in COVID-19

Severe cases of COVID-19 can involve extensive inflammation in the body, and clinicians have wondered if this state is similar to what are called cytokine storm syndromes. A new study indicates that different markers in the blood clearly differentiate excessive inflammation in critical COVID-19 from cytokine storm syndromes. from Top Health News -- ScienceDaily https://ift.tt/3vdrQMn via IFTTT

Disrupted sleep is linked to increased risk of early death, particularly in women

For the first time, a study has shown a clear link between the frequency and duration of unconscious wakefulness during night-time sleep and an increased risk of dying from diseases of the heart and blood vessels, and death from any cause, particularly in women. from Top Health News -- ScienceDaily https://ift.tt/3xaXvQ5 via IFTTT

Drug development platform could provide flexible, rapid and targeted antimicrobials

Researchers have created a platform that can develop effective and highly specific peptide nucleic acid therapies for use against any bacteria within just one week. The work could change the way we respond to pandemics and how we approach increasing cases of antibiotic resistance globally. from Top Health News -- ScienceDaily https://ift.tt/3sBEZwP via IFTTT

Reversal of blood droplet flight predicted, captured in experiments

To search for answers about how blood droplets from a gunshot wound can reverse direction while in flight, researchers explored the influence of propellant gases on blood backspatter. They report using numeric modeling to capture the behavior of gun muzzle gases and predict the reversal of blood droplet flight, which was captured experimentally. Their experiments also show the breakup of blood droplets, a future extension of their modeling efforts. from Top Health News -- ScienceDaily https://ift.tt/3godJPV via IFTTT

A gene finding links severe canine juvenile epilepsy to mitochondrial dysfunction

Researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps. Concurrently, amyloid-beta accumulation and widespread neurodegeneration associated with Alzheimer's disease were identified in the puppies' brains. Changes to the PITRM1 gene in humans also cause a severe but slowly progressing brain disease. from Top Health News -- ScienceDaily https://ift.tt/2RPmFDU via IFTTT

Chickens and pigs with integrated genetic scissors

Genetically engineered animals provide important insights into the molecular basis of health and disease. Research has focused mainly on genetically modified mice, although other species, such as pigs, are more similar to human physiology. Researchers have now generated chickens and pigs in which target genes in desired organs can be efficiently altered. from Top Health News -- ScienceDaily https://ift.tt/3suvPlS via IFTTT

Organ tissues become increasingly immune throughout life

Researchers have offered new ways to think about the immune system. The research, which indicates organ tissues become increasingly immune throughout life, may begin to alter fundamental ideas regarding the rules of vaccination and the immune system's function within the body. from Top Health News -- ScienceDaily https://ift.tt/3ekkyiS via IFTTT

Our attention is captured by eye-glance

Researchers looked at the way we process human gaze, focusing on the estimation of the temporal duration of social interactions. They discovered that when we make eye contact with another person, our attention is solicited, causing a distortion in our temporal perception: time seems shorter than it really is. These results will make it possible to develop a diagnostic tool to evaluate the mechanisms at work in people who are sensitive to social gaze. from Top Health News -- ScienceDaily https://ift.tt/2P66mS1 via IFTTT

Supplement treats schizophrenia in mice, restores healthy 'dance' and structure of neurons

A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons' cellular skeletons. from Top Health News -- ScienceDaily https://ift.tt/3ekAAJt via IFTTT

Flushing a public toilet? Don't linger, because aerosolized droplets do

Because COVID-19 has been detected in urine and stool samples, public restrooms can be cause for concern. Researchers measured droplets generated from flushing a toilet and a urinal in a public restroom and found a substantial increase in the measured aerosol levels in the ambient environment with the total number of droplets generated in each flushing test ranging up to the tens of thousands. Due to their small size, these droplets can remain suspended for a long time. from Top Health News -- ScienceDaily https://ift.tt/2RET6Vl via IFTTT

Tiny implantable tool for light-sheet imaging of brain activity

Tools for optical imaging of brain activity in freely moving animals have considerable potential for expanding the scientific understanding of the brain. However, existing technologies for imaging brain activity with light have challenges. An international team of scientists has now developed an implantable probe for light-sheet imaging of the brain. from Top Health News -- ScienceDaily https://ift.tt/2P3HUAR via IFTTT

DNA robots designed in minutes instead of days

Someday, scientists believe, tiny DNA-based robots and other nanodevices will deliver medicine inside our bodies, detect the presence of deadly pathogens, and help manufacture increasingly smaller electronics. Researchers took a big step toward that future by developing a new tool that can design much more complex DNA robots and nanodevices than were ever possible before in a fraction of the time. from Top Health News -- ScienceDaily https://ift.tt/2QHpFkU via IFTTT

Once-a-week insulin treatment could be game-changing for patients with diabetes

Treating people with Type 2 diabetes with a new once-a-week injectable insulin therapy proved to be safe and as effective as daily insulin injections, according to the results of two international clinical trials. The studies suggest that the once-weekly treatment could provide a convenient alternative to the burden of daily insulin shots for diabetes patients. from Top Health News -- ScienceDaily https://ift.tt/3eehrsN via IFTTT

Your neighborhood may affect your brain health

Middle-age and older people living in more disadvantaged neighborhoods -- areas with higher poverty levels and fewer educational and employment opportunities--had more brain shrinkage on brain scans and showed faster decline on cognitive tests than people living in neighborhoods with fewer disadvantages, according to a new study. from Top Health News -- ScienceDaily https://ift.tt/3n10fLf via IFTTT

Intellectual disability is rarely inherited -- risk for younger siblings is low

Intellectual disability is most often caused by changes to the genome that take place in early fetal development and are not found in the parents' DNA. This is why the risk of recurrence in the next sibling of the family is very small, as indicated by a recent study. from Top Health News -- ScienceDaily https://ift.tt/3v5AmNs via IFTTT

Defects in a specific cell type may cause ulcerative colitis

There are many variants of 'goblet cells' in the intestines and they seem to have different functions, according to a new study. The study indicates that defects in goblet cells of a particular type may be a factor contributing to ulcerative colitis, an inflammatory bowel disease. from Top Health News -- ScienceDaily https://ift.tt/32wIbz6 via IFTTT

Gender-affirming hormone therapy may increase risk of high blood pressure

Transgender and gender-diverse people have higher rates of hypertension compared to the general population. Within two to four months of starting gender-affirming hormone therapy, transgender women had a lower average systolic blood pressure, and transgender men had a higher average systolic blood pressure. from Top Health News -- ScienceDaily https://ift.tt/3srSn6B via IFTTT

How to make online arguments productive

Researchers worked with almost 260 people to understand online disagreements and to develop potential design interventions that could make these discussions more productive and centered around relationship-building. from Top Health News -- ScienceDaily https://ift.tt/3ed193m via IFTTT

Uncovering the secret of the hunger switch in the brain

Researchers have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. from Top Health News -- ScienceDaily https://ift.tt/3eaKYnj via IFTTT

Impacts of coronavirus lockdowns: New study collects data on pollutants in the atmosphere

One consequence of the coronavirus pandemic has been global restrictions on mobility. This, in turn, has had an effect on pollution levels in the atmosphere. Researchers from across the world are using this unique opportunity to take measurements, collect data, and publish studies. An international team has now published a comprehensive review providing an overview of results up to September 2020. from Top Health News -- ScienceDaily https://ift.tt/2QvKhwC via IFTTT

Genetic ancestry versus race can provide specific, targeted insights to predict and treat many diseases

The complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases -- insights that are far more targeted and specific than those derived from traditional ethnic or racial labels like Hispanic or Black, according to researchers. from Top Health News -- ScienceDaily https://ift.tt/3ty541k via IFTTT

Treatment not always needed to prevent vision loss in patients with elevated eye pressure

The national Ocular Hypertension Treatment Study was designed to determine whether lowering elevated eye pressure in patients might prevent vision loss from glaucoma. Researchers recently completed follow-up studies on patients 20 years after the start of the original study and found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma. from Top Health News -- ScienceDaily https://ift.tt/3ajdQIE via IFTTT

New benefits from anti-diabetic drug metformin

Researchers have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure drug losartan, so researchers believe that a combination these medications at low dose will be highly beneficial. from Top Health News -- ScienceDaily https://ift.tt/3eeiRne via IFTTT

New type of cell contributes to increased understanding of ALS

The causes of the serious muscle disease ALS still remain unknown. Now, researchers have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and vascular systems. The study has potential implications for earlier diagnoses and future treatments. from Top Health News -- ScienceDaily https://ift.tt/3amyAzj via IFTTT

In surprising twist, some Alzheimer's plaques may be protective, not destructive

One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. New research upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful. from Top Health News -- ScienceDaily https://ift.tt/32sgtU8 via IFTTT

A more complete account

Even the mention of parasites can be enough to make some people's skin crawl. But to recent UC Santa Barbara doctoral graduate Dana Morton these creepy critters occupy important ecological niches, fulfilling roles that, in her opinion, have too often been overlooked. from Top Health News -- ScienceDaily https://ift.tt/3alHsFz via IFTTT

New 'time machine' technique to measure cells

Using a new single-cell technique, researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. The research uncovered new genes that program stem cells to make the dendritic cells that kick-start the immune response. By uncovering this process, the researchers hope they will be able to find new immunotherapy treatments for cancer, and plan to expand this technique in other areas such as discovering new drug targets. from Top Health News -- ScienceDaily https://ift.tt/3dvR2I1 via IFTTT

Objective analysis of stress in the classroom

Is it the difficulty of a task that determines whether or not students are stressed when working on it? Biologists working in biology didactics set out to find out the answers; to this end, the team used questionnaires and measured the heart rate in 209 test participants. from Top Health News -- ScienceDaily https://ift.tt/3mTMNZy via IFTTT

Keeping fit with HIIT really does work

Recently, researchers have been studying whether shorter variations of HIIT, involving as little as 4-min of high intensity exercise per session (excluding a warm up and cool down), also improve health. A new review paper collates a decade's worth of research on the topic of this so-called low-volume high HIIT for health. from Top Health News -- ScienceDaily https://ift.tt/3mXqsKY via IFTTT

An ion pump to deliver chemotherapy agents to the brain

Despite surgery and subsequent treatment with chemotherapy and radiation, the majority of patients experience recurrence of malignant brain tumors. Researchers have shown in cells in culture that an ion pump can deliver drugs more accurately, which gives less severe adverse effects in chemotherapy. from Top Health News -- ScienceDaily https://ift.tt/3uZ5H44 via IFTTT

Highly dense urban areas are not more vulnerable to COVID-19, researchers say

A person who owns a car or who has a college education may be less vulnerable to COVID-19, according to an analysis of cases in Tehran, Iran, one of the early epicenters of the pandemic. While such variables do not inherently lower a person's risk, they do indicate an infrastructure of protection that persists despite how densely populated a person's district might be. from Top Health News -- ScienceDaily https://ift.tt/3aly7O1 via IFTTT

Research shows to disrupt online extremism freewill is key

According to new research, when people are explicitly told that they are free to accept or reject propagandistic claims, the likelihood of choosing a moderate view increases. This was a result of a survey of attitudes that tested counter-propaganda strategies, which stressed a person's autonomy, and then measured sentiments after exposure. from Top Health News -- ScienceDaily https://ift.tt/2Qc2NKH via IFTTT

New method of artificially creating genetic switches for yeast

A group of researchers has successfully developed a flexible and simple method of artificially producing genetic switches for yeast, a model eukaryotic organism. Genetic switches are necessary in order to artificially generate new functions in an organism. The researchers established a platform for creating genetic switches that could be applied to the development of sophisticated, artificially controlled yeast cells to produce large quantities of valuable compounds. from Top Health News -- ScienceDaily https://ift.tt/32pecck via IFTTT

Norovirus clusters are resistant to environmental stresses and UV disinfection

Clusters of a virus known to cause stomach flu are resistant to detergent and ultraviolet disinfection, according to new research. The findings suggest the need to revisit current disinfection, sanitation and hygiene practices aimed at protecting people from noroviruses. from Top Health News -- ScienceDaily https://ift.tt/2Qx15Dy via IFTTT

Two distinct types of COVID-19-associated acute respiratory distress syndrome identified

Identifying subsets of patients with different biochemical characteristics can help clinical researchers develop more effective therapies for treating ARDS associated with COVID-19 infections. Results of a new study suggest that disruption of the normal regulation of blood vessels and circulation could be a key feature of critical illness, severe symptoms, and death related to COVID-19 infections. from Top Health News -- ScienceDaily https://ift.tt/3e7h7Mu via IFTTT

New measure to predict stress resilience

Researchers show that increased sensitivity in a specific region of the brain contributes to the development of anxiety and depression in response to real-life stress. Their study establishes an objective neurobiological measure for stress resilience in humans. from Top Health News -- ScienceDaily https://ift.tt/3skaQSx via IFTTT

How to gain a sense of well-being, free and online

In 2018, when Professor Laurie Santos introduced her course 'Psychology and the Good Life,' a class on the science of happiness, it became the most popular in the history of Yale, attracting more than 1,200 undergraduate enrollees that first semester. An online course based on those teachings became a global phenomenon. By latest count, 3.38 million people have enrolled to take the free Coursera.org course, called 'The Science of Well Being.' from Top Health News -- ScienceDaily https://ift.tt/3gfpIiJ via IFTTT

How we can reduce food waste and promote healthy eating

Food waste and obesity are major problems in developed countries. They are both caused by an overabundance of food, but strategies to reduce one can inadvertently increase the other. A broader perspective can help identify ways to limit food waste while also promoting healthy nutrition, researchers suggest. from Top Health News -- ScienceDaily https://ift.tt/2PZv9I8 via IFTTT

The architect of genome folding

The DNA molecule is not naked in the nucleus. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This 3D spatial genome organization is fundamental for the regulation of our genes and has to be established de novo by each individual during early embryogenesis. Researchers now reveal a yet unknown and critical role of the protein HP1a in the 3D genome re-organization after fertilization. The study identifies HP1a as an epigenetic regulator that is involved in establishing the global structure of the genome in the early Drosophila embryo. from Top Health News -- ScienceDaily https://ift.tt/3tsizzq via IFTTT

Those who had COVID-19 may only need one vaccine dose, study suggests

Those recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, but little immune benefit after the second dose, according to new research. The findings suggest only a single vaccine dose may be needed to produce a sufficient antibody response. Those who did not have COVID-19 did not have a full immune response until after receiving their second vaccine, reinforcing the importance of the two recommended doses. from Top Health News -- ScienceDaily https://ift.tt/3eaLmlP via IFTTT

A neuromagnetic view through the skull

The brain processes information using both slow and fast currents. Until now, researchers had to use electrodes placed inside the brain in order to measure the latter. Researchers have now successfully visualized these fast brain signals from the outside -- and found a surprising degree of variability. from Top Health News -- ScienceDaily https://ift.tt/3dmsoJv via IFTTT

Scientists generate human-monkey chimeric embryos

Investigators have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time -- up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease. from Top Health News -- ScienceDaily https://ift.tt/3sv3XhD via IFTTT

One year of SARS-CoV-2 evolution

Researchers have published an in-depth look at the SARS-CoV-2 mutations that have taken place during the past year. The review discusses the findings of over 180 research articles and follows the changes that have taken place in the SARS-CoV-2 genome, and the variants that have occurred as a result. from Top Health News -- ScienceDaily https://ift.tt/3wWknmp via IFTTT

Lipid research may help solve COVID-19 vaccine challenges

New research could help solve a major challenge in the deployment of certain COVID-19 vaccines worldwide -- the need for the vaccines to be kept at below-freezing temperatures during transport and storage. Researchers demonstrate a new, inexpensive technique that generates crystalline exoskeletons around delicate liposomes and other lipid nanoparticles and stabilizes them at room temperature. from Top Health News -- ScienceDaily https://ift.tt/3mOmgNe via IFTTT