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Showing posts from December, 2021

Early warning signals could help monitor disease outbreaks

New research suggests early warning signals (EWSs) could help in the monitoring of disease outbreaks, such as COVID-19. The study found warnings could be detected weeks earlier than any rapid increase in cases. The findings could help governments and policy makers improve the accuracy of their decisions and allow timely interventions if needed. from Top Health News -- ScienceDaily https://ift.tt/3DvxDk4 via IFTTT

Early warning signals could help monitor disease outbreaks

New research suggests early warning signals (EWSs) could help in the monitoring of disease outbreaks, such as COVID-19. The study found warnings could be detected weeks earlier than any rapid increase in cases. The findings could help governments and policy makers improve the accuracy of their decisions and allow timely interventions if needed. from Top Health News -- ScienceDaily https://ift.tt/3DvxDk4 via IFTTT

Protein variant identified that renders chemotherapy ineffective in gastric cancer

A new protein variant underlies the ability of gastric cancers to resist an otherwise effective family of chemotherapy drugs, according to a study by a multidisciplinary team. The results suggest a treatment strategy that could improve the prognoses of many patients with cancer. from Top Health News -- ScienceDaily https://ift.tt/3rOhDY6 via IFTTT

Researchers identify sildenafil as candidate drug for Alzheimer’s disease

A new study has identified sildenafil -- an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Ravatio) -- as a promising drug candidate to help prevent and treat Alzheimer's disease. Researchers determined that sildenafil is associated with 69% reduced incidence of Alzheimer's. from Top Health News -- ScienceDaily https://ift.tt/31G0OUu via IFTTT

Global database of plants reveals human activity biggest driver of homogenization of plant communities

Researchers compile a dataset of over 200,000 plant species worldwide to demonstrate the extent to which species extinctions and non-native invasive plants reorganize plant communities in the Anthropocene revealing biotic homogenization results from human activity whether intentional or unintentional. from Top Health News -- ScienceDaily https://ift.tt/3GihEYi via IFTTT

Scientists find first in human evidence of how memories form

In a discovery that could one day benefit people suffering from traumatic brain injury, Alzheimer's disease, and schizophrenia, researchers have identified the characteristics of more than 100 memory-sensitive neurons that play a central role in how memories are recalled in the brain. from Top Health News -- ScienceDaily https://ift.tt/3dvjjxf via IFTTT

Researchers crack the synthetic code of rare molecules sought after in drug development

A research team has succeeded in producing two molecules that are otherwise only formed by microorganisms from extremely contaminated wastewater in an abandoned mine in South Korea. The method, which took four years to develop, could pave the way for new types of drugs. from Top Health News -- ScienceDaily https://ift.tt/3rFWNdB via IFTTT

Minimal effort required: A ten-minute run can boost brain processing

Researchers found that as little as ten minutes of moderate-intensity running could benefit mental health. In study participants, both mood and cognitive functions improved, and the activation of bilateral prefrontal subregions associated with cognitive function and mood also increased. These results demonstrate the potential advantages of exercise prescriptions for various conditions including mental health treatment. from Top Health News -- ScienceDaily https://ift.tt/3EwazmC via IFTTT

Spaceflight wreaks havoc on liver metabolism

Researchers have demonstrated that microgravity and other environmental factors in space play different roles in inducing oxidative stress, which, in turn, alters the metabolism of sulfur-containing compounds in the liver of mice. The study highlighted steps that can be taken, such as boosting antioxidant capacity with dietary supplements, to safeguard astronaut health. from Top Health News -- ScienceDaily https://ift.tt/3lEruvS via IFTTT

Glucose control is a key factor for reduced cancer risk in obesity and type 2 diabetes

Good glucose control is important for reduction of cancer risk in obesity and type 2 diabetes. Large durable weight loss, as such, appears to afford protection against cancer, but with good glucose control the number of cancer cases also drops radically, a new study shows. from Top Health News -- ScienceDaily https://ift.tt/3dmb4nk via IFTTT

Cataract surgery linked with lessened dementia risk

Based on the longitudinal data of over 3,000 study participants, researchers found that subjects who underwent cataract surgery had nearly 30% lower risk of developing dementia from any cause compared with those who did not. This lowered risk persisted for at least a decade after surgery. Cataract surgery was also associated with lower risk of Alzheimer disease dementia specifically. from Top Health News -- ScienceDaily https://ift.tt/3Ey2Owy via IFTTT

Discovering new drugs with help from Darwinian principles

Our body must constantly defend itself against bacteria and viruses. It generates millions of different antibodies, which are selected to recognise the enemy and trigger the best possible immune response. Scientists use these antibodies to for therapeutic purposes to target proteins and disrupt their harmful. However, identifying the small molecules that will form the basis of the drug is a long and tedious process. Chemists have now developed a technique inspired by the theory of Darwinian evolution: amplifying the best combinations and generating diversity allows biology to find solutions to new problems. from Top Health News -- ScienceDaily https://ift.tt/31CmVuB via IFTTT

X-ray laser reveals how radiation damage arises

An international research team has used the X-ray laser European XFEL to gain new insights into how radiation damage occurs in biological tissue. The study reveals in detail how water molecules are broken apart by high-energy radiation, creating potentially hazardous radicals and electrically charged ions, which can go on to trigger harmful reactions in the organism. from Top Health News -- ScienceDaily https://ift.tt/31zwY3V via IFTTT

How you speak up at work can affect whether you’re picked for a team

Business leaders and management experts often encourage people to speak up in the workplace. Suggesting a creative idea or a more efficient way to work can help companies overcome challenges and meet goals. But new research shows another, more subtle and often overlooked form of speaking up has a big effect on the way work gets done and how teams come together. from Top Health News -- ScienceDaily https://ift.tt/3InDvzB via IFTTT

Understanding mouthfeel of food using physics

Our understanding of how microscopic structure and changes in the shape of food affect food texture remains underdeveloped, so researchers from Denmark and Germany conducted a series of experiments relating food microstructure and rheology to texture. They used coherent anti-Stokes Raman scattering microscopy to relate the molecular makeup of the fat in foods with the rheological and mechanical properties of the food. The foods in question: foie gras and pâté. from Top Health News -- ScienceDaily https://ift.tt/3diNK9V via IFTTT

Printing technique creates effective skin equivalent, heals wounds

Researchers have developed an approach to print skin equivalents, which may play a future role in facilitating the healing of chronic wounds. They used suspended layer additive manufacturing, creating a gel-like material to support the skin equivalent that can then support a second phase of gel injection. During printing, the skin layers are deposited within the support gel. After printing, the team washed away the support material, leaving behind the layered skin equivalent. from Top Health News -- ScienceDaily https://ift.tt/31qumWd via IFTTT

ALS therapy should target brain, not just spine

The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), scientists have discovered. This flips a long-standing belief the disease starts in the spinal motor neurons and any therapy would need to target the spine as the key focus. The new study shows the brain degenerates early in ALS, sends warning signals and shows defects very early in the disease. Degeneration of brain motor neurons is not merely a byproduct of the spinal motor neuron degeneration, as had been previously thought. from Top Health News -- ScienceDaily https://ift.tt/3rzqRrd via IFTTT

Predicting protein-protein interactions

Scientists have collaborated to build a structurally-motivated deep learning method built from recent advances in neural language modeling. The team's deep-learning model, called D-SCRIPT, was able to predict protein-protein interactions (PPIs) from primary amino acid sequences. from Top Health News -- ScienceDaily https://ift.tt/3DntT48 via IFTTT

Brain drain: Scientists explain why neurons consume so much fuel even when at rest

Pound for pound, the brain consumes vastly more energy than other organs, and, puzzlingly, it remains a fuel-guzzler even when its neurons are not firing signals called neurotransmitters to each other. Now researchers have found that the process of packaging neurotransmitters may be responsible for this energy drain. from Top Health News -- ScienceDaily https://ift.tt/3EBkF5q via IFTTT

Genes associated with hearing loss visualized in new study

Researchers have been able to document and visualize hearing loss-associated genes in the human inner ear, in a unique collaboration study between otosurgeons and geneticists. The findings illustrate that discrete subcellular structures in the human organ of hearing, the cochlea, are involved in the variation of risk of age-related hearing loss in the population. from Top Health News -- ScienceDaily https://ift.tt/3ruD0O4 via IFTTT

Unlocking the cause of UTI-induced delirium

Researchers have found that blocking the action of a protein called interleukin 6 (IL-6), part of the immune system, could resolve the delirium that often accompanies urinary tract infection (UTI) in elderly patients. Their study could pave the way for clinical trials of IL-6 inhibitors as a treatment for UTI-associated delirium in humans. from Top Health News -- ScienceDaily https://ift.tt/3rxXQfn via IFTTT

Building a human body through gastrulation

Researchers offer a phylogenetic and ontogenetic overview of the primitive streak and its role in mediating amniote (vertebrate animals that develop on land) gastrulation, and discuss the implications of embryonic stem cell-based models of early mammalian embryogenesis on the function of this structure. from Top Health News -- ScienceDaily https://ift.tt/3ltBRCn via IFTTT

Elevated heart rate linked to increased risk of dementia

Having an elevated resting heart rate in old age may be an independent risk factor of dementia, according to a new study. Since resting heart rate is easy to measure and can be lowered through exercise or medical treatment, the researchers believe that it may help to identify people with higher dementia risk for early intervention. from Top Health News -- ScienceDaily https://ift.tt/3ohtjR6 via IFTTT

Tracking the neurons that make us social

Human beings, like most mammals, need social interactions to live and develop. The processes that drive them towards each other require decision making whose brain machinery is largely misunderstood. To decipher this phenomenon, a team has studied the neurobiological mechanisms at stake when two mice come into contact through learning a task. They observed that the motivation to invest in a social interaction is closely linked to the reward system, via the activation of dopaminergic neurons. from Top Health News -- ScienceDaily https://ift.tt/3ojtRG2 via IFTTT

Researchers attacking menacing ‘superbug’

Scientists around the world have been working in earnest to improve understanding of an increasingly virulent superbug, Clostridium difficile. The highly contagious hospital-acquired pathogen, designated by the Centers for Disease Control and Prevention as one of the five most urgent threats to the U.S. healthcare system, causes more than 500,000 infections and 29,000 deaths each year at a total societal cost exceeding $5 billion. from Top Health News -- ScienceDaily https://ift.tt/3dbxiIF via IFTTT

Shining new light on elusive flying bats

How can we understand the activity of wild bats? Mostly soundless, flying in the dark, bats feed at night and evade our senses. Now, an international research team has developed a new non-invasive method 'bat point counts' by combining modern sensing technologies -- thermal, ultrasonic and near-infrared -- to detect, identify and count all bats flying around in a certain range. from Top Health News -- ScienceDaily https://ift.tt/3EluVin via IFTTT

Stroke may be triggered by anger, emotional upset and heavy physical exertion

A global study into causes of stroke has found that one in 11 survivors experienced a period of anger or upset in the one hour leading up to it. One in 20 patients had engaged in heavy physical exertion. The suspected triggers have been identified as part of the global INTERSTROKE study, which analyzed 13,462 cases of acute stroke, involving patients with a range of ethnic backgrounds in 32 countries. from Top Health News -- ScienceDaily https://ift.tt/2ZTIZRe via IFTTT

Parent-teacher relationship vital to home schooling

A research survey of primary school teachers in England has emphasized the importance of the relationship between parents and primary schools during lockdown school closures. 84% of teachers said they felt some pupils were disadvantaged by their home circumstances. from Top Health News -- ScienceDaily https://ift.tt/3IiWDOU via IFTTT

Language used by researchers to describe human populations has evolved over the last 70 years

Researchers have found that the words that scientists use to describe human populations -- such as race, ancestry, and ethnicity -- significantly changed from 1949 to 2018. Such changes and their timing, along with new descriptors for certain population groups, may be linked to structural racism, social trends, and how people view social constructs such as race. from Top Health News -- ScienceDaily https://ift.tt/3ofA1XB via IFTTT

Two-photon microscope provides unprecedented brain-imaging ability

Advancing our understanding of the human brain will require new insights into how neural circuitry works in mammals, including laboratory mice. These investigations require monitoring brain activity with a microscope that provides resolution high enough to see individual neurons and their neighbors. from Top Health News -- ScienceDaily https://ift.tt/3xRqlWv via IFTTT

Studies of children’s stories shows differences in Russian, US approaches to emotion

Recent research of parents in Russia and the United States, as well as children's literature in both countries, highlights how cultural differences in socializing emotions begin before children even start attending school. Specifically, the research found that Russian parents are more likely than U.S. parents to read stories to their children that feature negative emotions, such as fear, anger and sadness. from Top Health News -- ScienceDaily https://ift.tt/3lqlWow via IFTTT

Stem cell-based implants successfully secrete insulin in patients with type 1 diabetes

Interim results from a multicenter clinical trial demonstrate insulin secretion from engrafted cells in patients with type 1 diabetes. The safety, tolerability, and efficacy of the implants, which consisted of pancreatic endoderm cells derived from human pluripotent stem cells (PSCs), were tested in 26 patients. While the insulin secreted by the implants did not have clinical effects in the patients, the data are the first reported evidence of meal-regulated insulin secretion by differentiated stem cells in human patients. from Top Health News -- ScienceDaily https://ift.tt/3xNAi7s via IFTTT

New way of identifying early risk of cardiovascular disease

The risk of developing cardiovascular disease is strongly associated with 'bad' LDL cholesterol. A large study now shows that two proteins that transport cholesterol particles in the blood provide early and reliable risk information. The researchers now advocate introducing new guidelines for detecting cardiac risk and say the results may pave the way for early treatment, which could help lower morbidity and fatality rates. from Top Health News -- ScienceDaily https://ift.tt/3xLKsWb via IFTTT

Targeting the brain’s immune cells may help prevent or treat Alzheimer’s disease

A gene mutation linked to Alzheimer's disease alters a signaling pathway in certain immune cells of individuals with the disease, according to a new study. The team also found that blocking the pathway -- with a drug that's currently being tested in cancer clinical trials -- protects against many features of the condition in a preclinical model. The results could lead to new strategies to block the development of Alzheimer's disease or slow its progression. from Top Health News -- ScienceDaily https://ift.tt/3rpfH8k via IFTTT

Effectiveness of ointment that kills antibiotic-resistant bacteria shown

New research shows that use of a topical drug, called AB569, a combination of acidified nitrite and EDTA (or ethylenediaminetetraacetic acid) promotes killing of antibiotic-resistant bacteria while enhancing the healing of wounds in a variety of burn injuries. from Top Health News -- ScienceDaily https://ift.tt/3ErmAJK via IFTTT

Within an Antarctic sea squirt, scientists discover a bacterial species with promising anti-melanoma properties

Biologists have successfully traced a naturally-produced melanoma-fighting compound called 'palmerolide A' to its source: a microbe that resides within Synoicum adareanum, a species of ascidian common to the waters of Antarctica's Anvers Island archipelago. from Top Health News -- ScienceDaily https://ift.tt/3pBHfVF via IFTTT

Researchers identify key RNA 'gatekeeper' in gene expression, pointing to possible new drug targets

Researchers have identified the first non-coding RNA that controls formation of chromosome loops, which govern gene expression. Jpx RNA was previously thought to be involved only in X chromosome inactivation, a necessary step in development of female embryos. This discovery could create new targets for drug developers. from Top Health News -- ScienceDaily https://ift.tt/3xHCOvU via IFTTT

Biosensor barcodes identify, detail ‘chatting’ among cancer cells

Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. Scientists now demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells 'talk' with one another. from Top Health News -- ScienceDaily https://ift.tt/3pm8LpK via IFTTT

Parental stress is a contributing factor linking maternal depression to child anxiety and depressive symptoms

A secondary analysis of the Fragile Families and Child Wellbeing Study (Fragile Families) found a bi-directional relationship where a mother's mental health symptoms impacted the child's mental health symptoms and vice versa, according to researchers. from Top Health News -- ScienceDaily https://ift.tt/3lr1nIN via IFTTT

Footprints from site a at Laetoli, Tanzania, are from early humans, not bears

The oldest unequivocal evidence of upright walking in the human lineage are footprints discovered at Laetoli, Tanzania in 1978, by paleontologist Mary Leakey and her team. The bipedal trackways date to 3.7 million years ago. Another set of mysterious footprints was partially excavated at nearby Site A in 1976 but dismissed as possibly being made by a bear. A recent re-excavation of the Site A footprints at Laetoli and a detailed comparative analysis reveal that the footprints were made by an early human -- a bipedal hominin. from Top Health News -- ScienceDaily https://ift.tt/3xJKGNw via IFTTT

Successful treatment in mice for severe childhood cancer

In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study shows. This is a vital step toward a potentially curative treatment for a form of cancer affecting young children that is currently difficult to treat. from Top Health News -- ScienceDaily https://ift.tt/31k48ED via IFTTT

The diabetes medication that could revolutionize heart failure treatment

A medication originally used for patients with diabetes is the first to help people with heart failure and could revolutionize treatment. Early research had shown that SGLT2 inhibitors could help around half of heart failure patients -- those with a condition known as reduction ejection fraction. But a new study shows that the medication could be beneficial for all heart failure patients -- including those with a second type of heart failure called preserved ejection fraction. from Top Health News -- ScienceDaily https://ift.tt/3lttSpb via IFTTT

Aerogels: Airy and efficient

Researchers have developed a new photocatalyst made from an aerogel that could enable more efficient hydrogen production. The key is sophisticated pretreatment of the material. from Top Health News -- ScienceDaily https://ift.tt/3llGBtZ via IFTTT

Breakthrough tool to show how much exoskeletons reduce back injury risk

A study reveals a breakthrough tool to assess the effect of exoskeletons on injury risk. The tool, called Exo-LiFFT, is an interactive calculator that will help companies looking for ways to overcome workforces struggling with musculoskeletal injuries, missed work, and accelerated retirement amongst skilled laborers. from Top Health News -- ScienceDaily https://ift.tt/3poKorM via IFTTT

Potential new treatment for Alzheimer’s disease would be relatively cheap

Researchers have discovered a protein involved in the development of Alzheimer's disease. Studies in mice showed that eliminating this protein entirely or using drugs to block its function reduced physical changes in the brain associated with the disease and improved memory. Drug therapy that aims to block the protein's activity could be a more effective treatment than what is currently available, as well as being cheaper. from Top Health News -- ScienceDaily https://ift.tt/3rtzofc via IFTTT