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Early warning signals could help monitor disease outbreaks

New research suggests early warning signals (EWSs) could help in the monitoring of disease outbreaks, such as COVID-19. The study found warnings could be detected weeks earlier than any rapid increase in cases. The findings could help governments and policy makers improve the accuracy of their decisions and allow timely interventions if needed. from Top Health News -- ScienceDaily https://ift.tt/3DvxDk4 via IFTTT
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Reprogramming the wonder drug rapamycin allows creation of new small-molecule drugs

In the new study, the authors aimed to reprogram rapamycin by keeping the parts of rapamycin and tacrolimus that bind FKBP12 and changing the remaining half of the molecule in order to target completely new disease-associated proteins beyond mTOR and calcineurin.

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Pathomechanisms in heart disease discovered

The largest protein in the human body, titin, enables elastic movements of our muscles, including the heart. Mutations in the titin gene (TTN) that impair this function and lead to heart muscle disease. The pathomechanisms behind this -- i.e. why TTN mutations trigger disease -- were unclear until now. A team of experts has now investigated these pathomechanisms in more detail and has gained ground-breaking insights. from Top Health News -- ScienceDaily https://ift.tt/3EOEi9S via IFTTT
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