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Early warning signals could help monitor disease outbreaks

New research suggests early warning signals (EWSs) could help in the monitoring of disease outbreaks, such as COVID-19. The study found warnings could be detected weeks earlier than any rapid increase in cases. The findings could help governments and policy makers improve the accuracy of their decisions and allow timely interventions if needed. from Top Health News -- ScienceDaily https://ift.tt/3DvxDk4 via IFTTT
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Innovative mouse model pumps new blood into study of pediatric heart disease

Researchers have created a mouse model of restrictive cardiomyopathy, a disease in which the heart muscle becomes stiff and the heart is unable to properly fill with blood. Their data suggest that the disease results from the accumulation of mutant BAG3 protein, which interferes with the protein quality control system and the machinery for breaking down and recycling damaged proteins, disrupting the heart muscle components.

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Pathomechanisms in heart disease discovered

The largest protein in the human body, titin, enables elastic movements of our muscles, including the heart. Mutations in the titin gene (TTN) that impair this function and lead to heart muscle disease. The pathomechanisms behind this -- i.e. why TTN mutations trigger disease -- were unclear until now. A team of experts has now investigated these pathomechanisms in more detail and has gained ground-breaking insights. from Top Health News -- ScienceDaily https://ift.tt/3EOEi9S via IFTTT
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