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Early warning signals could help monitor disease outbreaks

New research suggests early warning signals (EWSs) could help in the monitoring of disease outbreaks, such as COVID-19. The study found warnings could be detected weeks earlier than any rapid increase in cases. The findings could help governments and policy makers improve the accuracy of their decisions and allow timely interventions if needed. from Top Health News -- ScienceDaily https://ift.tt/3DvxDk4 via IFTTT

Gamma-secretase 'buckles up' to reach its destination

New research has uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric subcomplexes are formed, which independently exit the ER and only afterwards assemble into a four-subunit complex. This 'buckle up' mechanism is thought to prevent premature assembly and activity.

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